This courses introduces Mathematica to senior undergraduate and graduate students. The course includes a tutorial on Mathematica followed by a number of statistical topics. In the tutorial we cover many of the most frequently used Mathematica concepts. Programming concepts are also illustrated by showing how Mathematica can be used to implement many well known APL idioms. The use of the Standard Mathematica Package, Statistics`LinearRegression` is illustrated. Then we move on to more advanced topics such as Linearizing Transformations in Regression, Bivariate Loess, Queueing Theory.